Male gonadal toxicity

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منابع مشابه

Extra-gonadal Choriocarcinoma in the Male.

F.N. Male, aged 47 (Hospital No. 61178). He first attended in 1952, aged 37, complaining of recurrent dyspepsia. Radiological examination revealed a small gastric ulcer on the lesser curve of the stomach. He failed to keep his outpatient appointments and was not seen again until his admission in December, 1961 with hiematemesis and melnna. On examination the only abnormality found was a liver e...

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Pituitary-gonadal axis in male undermasculinisation.

AIMS To study the value of assessing serum concentrations of luteinising hormone (LH), follicle stimulating hormone (FSH), testosterone, and dihydrotestosterone (DHT) in patients with male undermasculinisation not caused by androgen insensitivity. METHODS A retrospective study of a register of cases of male undermasculinisation (20 with abnormal testes, eight with 5alpha-reductase deficiency,...

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Male-mediated developmental toxicity

In recent years, the public has become more aware that exposure of males to certain agents can adversely affect their offspring and cause infertility and cancer. The hazards associated with exposure to ionising radiation have been recognised for nearly a century, but interest was aroused when a cluster of leukaemia cases was identified in young children living in Seascale, close to the nuclear ...

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Cytogenetic Alterations in Preimplantation Mice Embryos Following Male Mouse Gonadal Gamma-irradiation: Comparison of Two Methods for Reproductive Toxicity Screening

BACKGROUND Genome instability is a main cause of chromosomal alterations in both somatic and germ cells when exposed to environmental, physical and chemical genotoxicants. Germ cells especially spermatozoa are more vulnerable to suffering from DNA damaging agents during spermatogenesis and also more potent in transmitting genome instability to next generation. METHODS To investigate the effec...

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Male gonadal function before and after chemotherapy in prepubertal boys.

UNLABELLED We evaluated gonadal function in twenty prepubertal boys (6.87 +/- 3.84 years old) at diagnosis and 2.5 +/- 1.6 years after treatment for acute lymphoblastic leukaemia (ALL). We measured serum levels of inhibin B (RIA method), testosterone, FSH, LH (immunoenzymatic methods) and compared the results with controls (31 healthy boys in prepubertal stage). RESULTS Serum inhibin B levels...

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ژورنال

عنوان ژورنال: Pediatric Blood & Cancer

سال: 2009

ISSN: 1545-5009,1545-5017

DOI: 10.1002/pbc.22004